dgkB [2017-8-11 16:0:3]

diacylglycerol kinase

locus: BSU06720

pI: 5.64

mw: 33.18 kDa

protein length: 303 aa

gene length: 909 bp

function: biosynthesis of lipoteichoic acid

product: diacylglycerol kinase

essential: no

ec: 2.7.1.107

synonyms: yerQ

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.3|Biosynthesis of lipoteichoic acid]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.2|Biosynthesis of lipoteichoic acid]

Gene

Coordinates: 736,436 → 737,347

Phenotypes of a mutant

• essential [Pubmed|12682299], non-essential according to [Pubmed|28189581]

The protein

Paralogous protein(s)

• [protein|88AECCE90DC0D6C92C61AB8860A31A830A8DAC42|BmrU]

Structure

• [PDB|3S40] (from ''B. anthracis'', 32% identity, 68% similarity)

Expression and Regulation

Operons

• genes: [gene|943294ACA74067A8549056699E08DF5B82337976|dgkB]-[gene|B97ABE3233A27A7C8273ED9A1E688247DD37FD12|rlmCD]
  description: [Pubmed|22383849]

• genes: [gene|943294ACA74067A8549056699E08DF5B82337976|dgkB]-[gene|B97ABE3233A27A7C8273ED9A1E688247DD37FD12|rlmCD]-[gene|5B5014A68D777DB79179904D5FD3D14DEE0BF1F4|yefC]-[gene|D3F00747006D974A8635D4391E0C261A3276E6AB|dnmA]-[gene|2E55D086DD5023B98929FB8B61238C00E66B8BCB|yeeB]-[gene|DB1AAC91947A6008F631266E5CC85B58703AFD9D|yeeC]
  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-B448 (yerQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1447 NBRP B. subtilis, Japan]
• GP1391 ''dgkB::cat ltaS::aphA3'', available in [SW|Jörg Stülke]'s lab

References

Reviews

• 24819367

Original publications

• 17535816,22451476,28189581